AOD-9604
A modified growth hormone fragment that targets fat metabolism without hormonal side effects.
From $179/mo
How It Works
AOD-9604 mimics the lipolytic action of the C-terminal region of growth hormone by activating beta-3 adrenergic receptors on adipocytes, stimulating hormone-sensitive lipase (HSL) which catalyzes the breakdown of stored triglycerides into free fatty acids and glycerol. Simultaneously, it inhibits the activity of lipogenic enzymes including acetyl-CoA carboxylase and fatty acid synthase, reducing the conversion of excess calories into new fat storage. Unlike full-length GH, AOD-9604 does not bind the GH receptor with sufficient affinity to activate the JAK2/STAT5 signaling cascade responsible for IGF-1 production, growth promotion, and insulin resistance. This receptor selectivity is due to a disulfide bond modification in the peptide that alters its three-dimensional conformation.
Key Benefits
Clinical Research
AOD-9604 was developed at Monash University and evaluated in Phase 2 clinical trials for obesity. In a 12-week double-blind, placebo-controlled study (n=300), participants receiving 1 mg AOD-9604 daily showed statistically significant weight loss compared to placebo (2.8 kg vs 0.8 kg). While this magnitude was modest, the study confirmed the mechanism of action and established safety. No adverse effects on glucose metabolism, IGF-1 levels, or thyroid function were observed. Pre-clinical studies demonstrated that AOD-9604 reduced body fat in obese Zucker rats without affecting lean mass or growth parameters. The peptide received FDA GRAS status in 2014, and a human food additive petition was filed. Research by Heffernan et al. (2001) confirmed that the fat-reducing properties reside in the hGH 176-191 region and can be enhanced by the addition of a tyrosine residue.
Dosage & Administration
Dosage
Standard dosing is 250-300 mcg administered subcutaneously once daily, typically in the morning on an empty stomach. Some protocols use 500 mcg daily for the first 4-6 weeks before reducing to a maintenance dose of 250 mcg. Therapy is typically conducted in 12-week cycles. For optimal results, administer at least 30 minutes before eating and avoid high-glycemic foods shortly after dosing. Your GetPepWell physician will determine the appropriate dose and cycle length based on your goals and response.
Administration
Administered as a subcutaneous injection once daily, preferably in the morning before breakfast. Inject into the abdominal area, rotating sites to avoid tissue irritation. Use a 29-31 gauge insulin syringe. Administer on an empty stomach - food intake (particularly carbohydrates) within 30 minutes of injection may reduce effectiveness by elevating insulin levels, which opposes lipolysis. Some protocols include a fasting window of 1-2 hours post-injection for maximum effect. Can also be taken before exercise for enhanced fat oxidation during the workout.
Side Effects
- Generally very well-tolerated with minimal side effects in clinical trials
- Mild injection site reactions (redness, minor swelling)
- Occasional headache
- Transient mild nausea
- Mild flu-like symptoms during the first few days (uncommon)
Contra-indications
- Known hypersensitivity to AOD-9604 or any excipients
- Active cancer or history of cancer
- Pregnancy or breastfeeding
- Children under 18 years of age
- Severe hepatic or renal impairment
Drug Interactions
- Insulin - theoretical interaction as both affect lipid metabolism; monitor blood glucose
- Beta-blockers - may reduce the lipolytic response by blocking beta-3 adrenergic receptors
- Growth hormone - concurrent use is redundant and not recommended
Storage Info
Store lyophilized powder refrigerated at 36-46 degrees F (2-8 degrees C). After reconstitution with bacteriostatic water, store refrigerated and use within 30 days. Do not freeze. Protect from light. Gently swirl the vial when reconstituting; do not shake vigorously.
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