NAD+
Essential coenzyme for cellular energy, DNA repair, and longevity pathways.
From $199/mo
How It Works
NAD+ functions as an electron carrier in mitochondrial oxidative phosphorylation (complexes I and II), directly fueling ATP production. It serves as a substrate for poly(ADP-ribose) polymerases (PARPs), which detect and repair DNA strand breaks. NAD+ also activates all seven mammalian sirtuins (SIRT1-7), deacetylase enzymes that regulate gene expression, mitochondrial biogenesis, inflammatory signaling (NF-kB suppression), and cellular stress responses. Additionally, NAD+ is consumed by CD38, an ectoenzyme whose activity increases with age and inflammation, contributing to NAD+ depletion. Supplementation aims to restore the NAD+/NADH ratio and support these critical metabolic pathways.
Key Benefits
Clinical Research
Research published in Cell Metabolism demonstrated that NAD+ precursor supplementation increased NAD+ levels by 40-50% in human subjects and improved mitochondrial function markers. Studies in Science (2016) showed that restoring NAD+ levels in aged mice reversed mitochondrial dysfunction and improved muscle function to levels comparable to young mice. Clinical trials of NAD+ precursors (NMN, NR) have shown improvements in insulin sensitivity, arterial stiffness, and exercise capacity in older adults.
Dosage & Administration
Dosage
Subcutaneous injection: 100-250mg administered 2-3 times weekly. IV infusion (when available): 250-500mg weekly over 2-4 hours. Dosing is individualized based on baseline NAD+ status, age, and treatment goals. Your GetPepWell physician will establish an optimal protocol during your consultation.
Administration
Administered as a subcutaneous injection in the abdomen or thigh. Injection is straightforward and can be self-administered at home after instruction. Some patients may experience mild warmth or flushing at the injection site. Store reconstituted solution refrigerated and use within the timeframe specified by your pharmacy.
Side Effects
- Chest tightness or pressure during IV infusion (dose-rate dependent)
- Nausea, particularly with higher doses
- Flushing and warmth at injection site
- Headache
- Mild cramping
- Fatigue during initial treatment (temporary as cells adapt)
Contra-indications
- Active cancer (NAD+ may support rapidly dividing cells)
- Pregnancy or breastfeeding
- Known hypersensitivity to NAD+ or any formulation components
- Severe liver disease
Drug Interactions
- Chemotherapy agents - NAD+ may affect drug metabolism; consult oncologist
- Blood pressure medications - NAD+ may have mild vasodilatory effects
- Diabetes medications - monitor blood glucose as NAD+ may improve insulin sensitivity
Storage Info
Store lyophilized vials refrigerated at 36-46 degrees F (2-8 degrees C). After reconstitution, keep refrigerated and use within 14 days. Do not freeze. Protect from light.
NAD+ FAQ
Find answers to the most common questions about this treatment.
Related Products
Interested in NAD+?
Schedule a consultation with a licensed physician to see if this treatment is right for you.