How quickly will I notice effects from NAD+ therapy?

Many patients report improved energy and mental clarity within the first 1-2 weeks of treatment. More significant cellular and metabolic benefits develop over 4-8 weeks of consistent use. Your GetPepWell physician will monitor your progress and adjust dosing as needed.

Is injectable NAD+ better than oral supplements like NMN or NR?

Injectable NAD+ provides direct bioavailability, bypassing the digestive system where oral precursors (NMN, NR) must be converted through multiple enzymatic steps. This results in more predictable and rapid NAD+ level elevation. Your physician can help determine the best approach for your goals.

Anti-Aging

NAD+

Name: NAD+
Brand: GetPepWell
Price: 199.00 USD
Availability: InStock

Essential coenzyme for cellular energy, DNA repair, and longevity pathways.

Compounded preparation

From$199/mo

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How it works

NAD+ functions as an electron carrier in mitochondrial oxidative phosphorylation (complexes I and II), directly fueling ATP production. It serves as a substrate for poly(ADP-ribose) polymerases (PARPs), which detect and repair DNA strand breaks. NAD+ also activates all seven mammalian sirtuins (SIRT1-7), deacetylase enzymes that regulate gene expression, mitochondrial biogenesis, inflammatory signaling (NF-kB suppression), and cellular stress responses. Additionally, NAD+ is consumed by CD38, an ectoenzyme whose activity increases with age and inflammation, contributing to NAD+ depletion. Supplementation aims to restore the NAD+/NADH ratio and support these critical metabolic pathways.

Key benefits

Enhanced cellular energy production through mitochondrial support
Activation of sirtuin longevity pathways (SIRT1-7)
Improved DNA damage repair via PARP enzyme activation
Cognitive clarity and reduced brain fog
Support for healthy aging and cellular resilience
Improved metabolic function and insulin sensitivity

Clinical research

Research published in Cell Metabolism demonstrated that NAD+ precursor supplementation increased NAD+ levels by 40-50% in human subjects and improved mitochondrial function markers. Studies in Science (2016) showed that restoring NAD+ levels in aged mice reversed mitochondrial dysfunction and improved muscle function to levels comparable to young mice. Clinical trials of NAD+ precursors (NMN, NR) have shown improvements in insulin sensitivity, arterial stiffness, and exercise capacity in older adults.

Side effects

Chest tightness or pressure during IV infusion (dose-rate dependent)
Nausea, particularly with higher doses
Flushing and warmth at injection site
Headache
Mild cramping
Fatigue during initial treatment (temporary as cells adapt)

Contra-indications

Active cancer (NAD+ may support rapidly dividing cells)
Pregnancy or breastfeeding
Known hypersensitivity to NAD+ or any formulation components
Severe liver disease

Drug interactions

Chemotherapy agents - NAD+ may affect drug metabolism; consult oncologist
Blood pressure medications - NAD+ may have mild vasodilatory effects
Diabetes medications - monitor blood glucose as NAD+ may improve insulin sensitivity

Storage info

Store lyophilized vials refrigerated at 36-46 degrees F (2-8 degrees C). After reconstitution, keep refrigerated and use within 14 days. Do not freeze. Protect from light.

Common questions

NAD+ FAQ

Find answers to the most common questions about this treatment.

Interested in NAD+?

Schedule a consultation with a licensed physician to see if this treatment is right for you.