Glutathione
The master antioxidant for detoxification, immune support, and cellular protection.
From $149/mo
How It Works
Glutathione functions through multiple mechanisms: (1) Direct antioxidant activity - the sulfhydryl (-SH) group on cysteine donates electrons to neutralize reactive oxygen species (ROS) and reactive nitrogen species (RNS). (2) Detoxification - glutathione S-transferase enzymes conjugate GSH to toxins, drugs, and carcinogens, making them water-soluble for elimination via bile or urine. (3) Immune modulation - GSH is essential for lymphocyte proliferation, NK cell activity, and optimal T-cell function. (4) Antioxidant recycling - GSH regenerates oxidized vitamins C and E back to their active forms. (5) Protein protection - GSH prevents irreversible oxidation of protein thiol groups, maintaining enzyme function.
Key Benefits
Clinical Research
Research in the European Journal of Clinical Nutrition demonstrated that IV glutathione significantly increased blood GSH levels compared to oral supplementation. Studies in the Journal of Alternative and Complementary Medicine showed that glutathione supplementation improved markers of oxidative stress and immune function in older adults. Clinical research has also documented glutathione's role in supporting liver health and its potential benefits for skin lightening through inhibition of melanin synthesis.
Dosage & Administration
Dosage
Injectable: 200-600mg administered 1-3 times weekly via subcutaneous or intramuscular injection. IV infusion: 600-2000mg weekly when combined with other nutrients. Dosing is personalized based on oxidative stress markers, health goals, and physician assessment.
Administration
Administered as a subcutaneous or intramuscular injection. The injection is simple and can be self-administered at home. IV infusions are available through select partner clinics. Store reconstituted solution refrigerated and protect from light, as glutathione is sensitive to oxidation.
Side Effects
- Injection site irritation or mild pain
- Bloating or mild gastrointestinal discomfort
- Allergic reaction (rare)
- Headache
- Skin lightening with prolonged high-dose use
Contra-indications
- Known allergy to glutathione or sulfur-containing compounds
- Pregnancy or breastfeeding (insufficient safety data for injectable form)
- Asthma (IV glutathione may trigger bronchospasm in sensitive individuals)
Drug Interactions
- Chemotherapy drugs - glutathione may interfere with some cytotoxic agents; consult oncologist
- Acetaminophen - glutathione is involved in acetaminophen metabolism; high doses of either may interact
Storage Info
Store lyophilized powder refrigerated at 36-46 degrees F (2-8 degrees C). After reconstitution, use within 7 days and keep refrigerated. Protect from light. Do not freeze. Discard if solution appears discolored.
Glutathione FAQ
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